Abstract:
Purpose: Antenatal diagnosis of congenital cystic ade- nomatoid lung malformation (CCAM) is vital for disease surveillance and postnatal care. Ultrasono- graphy (US) has been the imaging gold standard for antenatal CCAM assessment. However, one of the limitations of US is the “vanishing phenomenon” caused by isoechogenicity of CCAM tissue and adja- cent normal lung parenchyma. Methods: Antenatal serial US were concurrently used with magnetic re- sonance imaging (MRI) to monitor macro- and mi- crocystic lesions. Results: In both pregnant women, antenatal US and MRI confirmed the presence, in the fetus, of cystic lesions and predicted disease regres- sion/progression as well as the need for postnatal sur- gical intervention. Several advantages were detected by using both—serial US and MRI (over serial US alone)—including improved signal intensity, exact volume size measurements, precise CCAM location in particular for patients with adverse ultrasound con- ditions. Both neonates underwent surgical resection and had an uneventful post-operative course. Con- clusions: Antenatal use of MRI as well as serial US improved information regarding tissue resolution and delineation of CCAM. The information from two im- aging modalities was complementary. Our literature review confirmed the emerging role of prenatal MRI for postnatal monitoring and management of CCAM.
Keywords: Congenital Cystic Adenomatoid Lung Malformation; Antenatal Serial Ultrasound Studies; Antenatal MRI; Imaging Surveillance
